I didn't realize they made 2 color thermal paper. This was fun to play with. I do not have a Brother printer, so I experimented to see how this would work in other printer models. The first thing to know is that this is reverse wound, so the print side is on the inside, and not the outside of the roll (like normal receipt paper would be). One of my thermal printers was unhappy with feeding a roll that rolled from the other side (the paper feed rollers would slip). The other printer was just fine with it. Since this is a thick label + backing roll, it is more rigid than a paper only roll, hence the slipping feed wheels. The printer that did work was one of my thermal photo printers, so it actually outputs different temperatures, to produce lighter or darker pixels. When used with this paper, it produced mostly light and dark RED color (printing white to dark gray), and produced BLACK only on the darkest black pixels. What this means is that you will get a RED print out, with a normal print darkness setting, and a BLACK print out with your printer's darkest print setting. I wish I had time to write a custom driver for this. The standard Epson ESC command set does allow changes in darkness for each line. The challenge would be supporting 2 colors on a single line. It might be possible if there is a reverse feed command. That way you could print once at a light setting, for RED, then back feed and print a second pass, on dark, for BLACK. Enjoy.